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MedlinePlus Genetics vs Open Disease

Same instrument, two spec sheets — measured, not claimed.

APIMedlinePlus GeneticsHEALTHY79Open DiseaseHEALTHY94
Uptime · 30d
Uptime · 90d99.02%99.02%
Uptime · 30d98.3%98.3%
P50 · ms1877451
P95 · ms49421226
Authnonenone
CORSyesyes
HTTPSyesyes
Card requirednono
Commercial useunclearunclear
Data licenseU.S. National Library of Medicine (see NLM terms)Unverified (sources vary; see project repo)
Free tierFree — no key requiredFree — no key required
Rate limitUnpublishedUnpublished
In directory since2026-07-052026-07-05
operationalpartialdownno data

MedlinePlus Genetics vs Open Disease: common questions

Which is more reliable, MedlinePlus Genetics or Open Disease?

Both are neck-and-neck — MedlinePlus Genetics and Open Disease each measure 99.02% uptime over 90 days on our probe schedule. Reliability here is verified from our own scheduled checks; use the 30-day bars above to see which has been steadier lately.

Which is faster, MedlinePlus Genetics or Open Disease?

Open Disease has the lower median latency in our checks — MedlinePlus Genetics responds in 1877 ms versus Open Disease at 451 ms (P50). Tail latency (P95) is in the table above; for most workloads the median is the number that shapes how the API feels.

Do MedlinePlus Genetics and Open Disease need an API key?

Neither needs a paid key — MedlinePlus Genetics is callable with no signup, and Open Disease is callable with no signup. Both are quick to prototype with; rate limits still apply.

Can I call MedlinePlus Genetics and Open Disease from the browser?

Yes — both MedlinePlus Genetics and Open Disease send CORS headers over HTTPS, so front-end code can fetch either directly with no backend proxy. That makes them easy to swap in a client-side app while you compare responses.

Are MedlinePlus Genetics and Open Disease free for commercial use?

MedlinePlus Genetics has unclear commercial terms, and Open Disease has unclear commercial terms. We track service terms and the data license as separate fields — see the Commercial use and Data license rows above, and confirm both before shipping either in a paid product.