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ClinicalTrials.gov vs Open Disease

Same instrument, two spec sheets — measured, not claimed.

APIClinicalTrials.govHEALTHY77Open DiseaseHEALTHY94
Uptime · 30d
Uptime · 90d99.02%99.02%
Uptime · 30d100%98.3%
P50 · ms243451
P95 · ms5741226
Authnonenone
CORSyesyes
HTTPSyesyes
Card requirednono
Commercial useunclearunclear
Data licenseUnverifiedUnverified (sources vary; see project repo)
Free tierFree — limits not publishedFree — no key required
Rate limitUnpublishedUnpublished
In directory since2026-07-052026-07-05
operationalpartialdownno data

ClinicalTrials.gov vs Open Disease: common questions

Which is more reliable, ClinicalTrials.gov or Open Disease?

Both are neck-and-neck — ClinicalTrials.gov and Open Disease each measure 99.02% uptime over 90 days on our probe schedule. Reliability here is verified from our own scheduled checks; use the 30-day bars above to see which has been steadier lately.

Which is faster, ClinicalTrials.gov or Open Disease?

ClinicalTrials.gov has the lower median latency in our checks — ClinicalTrials.gov responds in 243 ms versus Open Disease at 451 ms (P50). Tail latency (P95) is in the table above; for most workloads the median is the number that shapes how the API feels.

Do ClinicalTrials.gov and Open Disease need an API key?

Neither needs a paid key — ClinicalTrials.gov is callable with no signup, and Open Disease is callable with no signup. Both are quick to prototype with; rate limits still apply.

Can I call ClinicalTrials.gov and Open Disease from the browser?

Yes — both ClinicalTrials.gov and Open Disease send CORS headers over HTTPS, so front-end code can fetch either directly with no backend proxy. That makes them easy to swap in a client-side app while you compare responses.

Are ClinicalTrials.gov and Open Disease free for commercial use?

ClinicalTrials.gov has unclear commercial terms, and Open Disease has unclear commercial terms. We track service terms and the data license as separate fields — see the Commercial use and Data license rows above, and confirm both before shipping either in a paid product.