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ClinicalTrials.gov vs MedlinePlus Genetics

Same instrument, two spec sheets — measured, not claimed.

APIClinicalTrials.govNEW—MedlinePlus GeneticsNEW—
Uptime · 30d
Uptime · 90d—%—%
Uptime · 30d—%—%
P50 · ms——
P95 · ms——
Authnonenone
CORSyesyes
HTTPSyesyes
Card requirednono
Commercial useunclearunclear
Data licenseUnverifiedU.S. National Library of Medicine (see NLM terms)
Free tierFree — limits not publishedFree — no key required
Rate limitUnpublishedUnpublished
In directory since2026-07-052026-07-05
operationalpartialdownno data

ClinicalTrials.gov vs MedlinePlus Genetics: common questions

Which is more reliable, ClinicalTrials.gov or MedlinePlus Genetics?

On our scheduled checks, MedlinePlus Genetics leads on measured uptime — ClinicalTrials.gov at —% versus MedlinePlus Genetics at —% over 90 days. These are our own probe results, not provider claims; the uptime bars above show the day-by-day record for both.

Do ClinicalTrials.gov and MedlinePlus Genetics need an API key?

Neither needs a paid key — ClinicalTrials.gov is callable with no signup, and MedlinePlus Genetics is callable with no signup. Both are quick to prototype with; rate limits still apply.

Can I call ClinicalTrials.gov and MedlinePlus Genetics from the browser?

Yes — both ClinicalTrials.gov and MedlinePlus Genetics send CORS headers over HTTPS, so front-end code can fetch either directly with no backend proxy. That makes them easy to swap in a client-side app while you compare responses.

Are ClinicalTrials.gov and MedlinePlus Genetics free for commercial use?

ClinicalTrials.gov has unclear commercial terms, and MedlinePlus Genetics has unclear commercial terms. We track service terms and the data license as separate fields — see the Commercial use and Data license rows above, and confirm both before shipping either in a paid product.