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ClinicalTrials.gov vs ES·pera API

Same instrument, two spec sheets — measured, not claimed.

APIClinicalTrials.govHEALTHY78ES·pera APIDYING37
Uptime · 30d
Uptime · 90d100%0.0%
Uptime · 30d100%0.0%
P50 · ms138—
P95 · ms3533—
Authnonenone
CORSyesno
HTTPSyesyes
Card requirednono
Commercial useunclearunclear
Data licenseUnverified
Free tierFree — limits not published
Rate limitUnpublished
In directory since2026-07-052026-09-21
operationalpartialdownno data

ClinicalTrials.gov vs ES·pera API: common questions

Which is more reliable, ClinicalTrials.gov or ES·pera API?

On our scheduled checks, ClinicalTrials.gov leads on measured uptime — ClinicalTrials.gov at 100% versus ES·pera API at 0.0% over 90 days. These are our own probe results, not provider claims; the uptime bars above show the day-by-day record for both.

Do ClinicalTrials.gov and ES·pera API need an API key?

Neither needs a paid key — ClinicalTrials.gov is callable with no signup, and ES·pera API is callable with no signup. Both are quick to prototype with; rate limits still apply.

Can I call ClinicalTrials.gov and ES·pera API from the browser?

Only ClinicalTrials.gov is browser-friendly — it returns CORS headers over HTTPS. ES·pera API needs a server-side call or proxy, so factor that into which one fits a front-end project.

Are ClinicalTrials.gov and ES·pera API free for commercial use?

ClinicalTrials.gov has unclear commercial terms, and ES·pera API has unclear commercial terms. We track service terms and the data license as separate fields — see the Commercial use and Data license rows above, and confirm both before shipping either in a paid product.